When vitamin D levels decrease, PTH increases, affecting intestinal absorption of vitamin D and skin conversion from its precursor. Hormone (PTH) is an important mediator of vitamin D status. The initial step in metabolic activation of vitamin D is an enzyme-catalyzed insertion of an OH group at carbon 25, resulting in 25(OH)D, the most abundant form of vitamin D in the circulation. Humans are able to metabolize both forms of vitamin D. There are 2 forms of vitamin D: ergocalciferol (or vitamin D2, synthesized by plants and fungi) and cholecalciferol (or vitamin D3, synthesized in human skin and by animals). In the future, this knowledge may enable us to fine-tune the dosing of vitamin D supplements during pregnancy, as well as identify subgroups of women who may be at greater risk of vitamin D deficiency. In turn, vitamin D metabolism during pregnancy is modulated by the individual’s genetic background. A growing body of evidence indicates that vitamin D can affect gene expression, including genes associated with immune defense pathways. From early in pregnancy, there is a rise in circulating levels of 1,25-dihydroxyvitamin D, but drop to prepregnancy levels after birth. Long known for its role as a preprohormone in calcium and bone homeostasis, our understanding of vitamin D now extends to its functions in regulating innate and adaptive Focus The initiation of human life at the moment of conception involves a myriad of ancient signaling hormones, which include vitamin D Early- Life Effects of Vitamin D: A Focus on Pregnancy and Lactation Key Insight
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |